Rabbit anti-Human USP3 Polyclonal Antibody

The antibody against USP3 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 321-520 of human USP3 (NP_006528.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.

ADA-11365A

Number

Cat.No	ADA-11365A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	USP3
Target Synonyms	UBP; SIH003; USP3	Form	Liquid
Species Reactivity	Human	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.01% thimerosal, pH7.3.	Purification Method	Affinity purification
Positive Samples	K-562	Application	ELISA, WB

Cat.No

ADA-11365A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

USP3

Target Synonyms

UBP; SIH003; USP3

Form

Liquid

Species Reactivity

Human

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.01% thimerosal, pH7.3.

Purification Method

Affinity purification

Positive Samples

K-562

Application

ELISA, WB

Immunogen Description	Recombinant fusion protein containing a sequence corresponding to amino acids 321-520 of human USP3 (NP_006528.2).	Target Species	Human
Immunogen Sequence	EVNCLICGTESRKFDPFLDLSLDIPSQFRSKRSKNQENGPVCSLRDCLRSFTDLEELDETELYMCHKCKKKQKSTKKFWIQKLPKVLCLHLKRFHWTAYLRNKVDTYVEFPLRGLDMKCYLLEPENSGPESCLYDLAAVVVHHGSGVGSGHYTAYATHEGRWFHFNDSTVTLTDEETVVKAKAYILFYVEHQAKAGSDKL	Uniprot ID	Q9Y6I4

Immunogen Description

Recombinant fusion protein containing a sequence corresponding to amino acids 321-520 of human USP3 (NP_006528.2).

Target Species

Human

Immunogen Sequence

EVNCLICGTESRKFDPFLDLSLDIPSQFRSKRSKNQENGPVCSLRDCLRSFTDLEELDETELYMCHKCKKKQKSTKKFWIQKLPKVLCLHLKRFHWTAYLRNKVDTYVEFPLRGLDMKCYLLEPENSGPESCLYDLAAVVVHHGSGVGSGHYTAYATHEGRWFHFNDSTVTLTDEETVVKAKAYILFYVEHQAKAGSDKL

Uniprot ID

Q9Y6I4

Background Information

Uniprot Id

Q9Y6I4
Target Species

Human
Target Name

USP3
Target Full Name

Ubiquitin carboxyl-terminal hydrolase 3
Target Function

Hydrolase that deubiquitinates monoubiquitinated target proteins such as histone H2A and H2B. Required for proper progression through S phase and subsequent mitotic entry. May regulate the DNA damage response (DDR) checkpoint through deubiquitination of H2A at DNA damage sites. Associates with the chromatin.
Target Subcellular Location

Nucleus. Note=Localizes preferentially with monoubiquitinated H2A to chromatin.
Target Protein Families

Peptidase C19 family, USP3 subfamily
Target Tissue Specificity

Expressed in all tissues examined, with strongest expression in pancreas.
Target Synonyms

Deubiquitinating enzyme 3; EC 3.1.2.15; SIH003; Ubiquitin carboxyl-terminal hydrolase 3; Ubiquitin specific peptidase 3; Ubiquitin specific processing protease 3; Ubiquitin Specific Protease 3; Ubiquitin thioesterase 3; Ubiquitin thiolesterase 3; Ubiquitin-specific-processing protease 3; UBP; UBP3_HUMAN; Usp3
Target Background

Enables histone binding activity and thiol-dependent deubiquitinase. Involved in several processes, including DNA repair; histone deubiquitination; and regulation of protein stability. Located in several cellular components, including Flemming body; cytoplasmic ribonucleoprotein granule; and nucleoplasm.

Rabbit anti-Human USP3 Polyclonal Antibody

Specifications

Immunogen Information

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