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The antibody against USP3 was raised in rabbit using the Recombinant Human Ubiquitin carboxyl-terminal hydrolase 3 protein (201-500AA) as the immunogen. This antibody exists as a biotin conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.
The antibody against USP3 was raised in rabbit using the Recombinant Human Ubiquitin carboxyl-terminal hydrolase 3 protein (201-500AA) as the immunogen. This antibody exists as a biotin conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.
$299.00
| Cat.No | ADC-17669A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | USP3 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Biotin conjugated |
| Application | ELISA | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Ubiquitin carboxyl-terminal hydrolase 3 protein (201-500AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9Y6I4 |
Uniprot Id
Q9Y6I4
Target Species
Human
Target Name
USP3
Target Full Name
Ubiquitin carboxyl-terminal hydrolase 3
Target Function
Hydrolase that deubiquitinates monoubiquitinated target proteins such as histone H2A and H2B. Required for proper progression through S phase and subsequent mitotic entry. May regulate the DNA damage response (DDR) checkpoint through deubiquitination of H2A at DNA damage sites. Associates with the chromatin.
Target Subcellular Location
Nucleus. Note=Localizes preferentially with monoubiquitinated H2A to chromatin.
Target Protein Families
Peptidase C19 family, USP3 subfamily
Target Tissue Specificity
Expressed in all tissues examined, with strongest expression in pancreas.
Target Synonyms
Deubiquitinating enzyme 3; EC 3.1.2.15; SIH003; Ubiquitin carboxyl-terminal hydrolase 3; Ubiquitin specific peptidase 3; Ubiquitin specific processing protease 3; Ubiquitin Specific Protease 3; Ubiquitin thioesterase 3; Ubiquitin thiolesterase 3; Ubiquitin-specific-processing protease 3; UBP; UBP3_HUMAN; Usp3
Target Background
Enables histone binding activity and thiol-dependent deubiquitinase. Involved in several processes, including DNA repair; histone deubiquitination; and regulation of protein stability. Located in several cellular components, including Flemming body; cytoplasmic ribonucleoprotein granule; and nucleoplasm.
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