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The antibody against USP30 was raised in rabbit using the Recombinant Human Ubiquitin carboxyl-terminal hydrolase 30 protein (101-400AA) as the immunogen. This antibody exists as a hrp conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.
The antibody against USP30 was raised in rabbit using the Recombinant Human Ubiquitin carboxyl-terminal hydrolase 30 protein (101-400AA) as the immunogen. This antibody exists as a hrp conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.
$299.00
| Cat.No | ADC-23024A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | USP30 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | HRP conjugated |
| Application | ELISA | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Ubiquitin carboxyl-terminal hydrolase 30 protein (101-400AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q70CQ3 |
Uniprot Id
Q70CQ3
Target Species
Human
Target Name
USP30
Target Full Name
Ubiquitin carboxyl-terminal hydrolase 30
Target Function
Deubiquitinating enzyme tethered to the mitochondrial outer membrane that acts as a key inhibitor of mitophagy by counteracting the action of parkin (PRKN): hydrolyzes ubiquitin attached by parkin on target proteins, such as RHOT1/MIRO1 and TOMM20, thereby blocking parkin's ability to drive mitophagy. Preferentially cleaves 'Lys-6'- and 'Lys-11'-linked polyubiquitin chains, 2 types of linkage that participate in mitophagic signaling. Does not cleave efficiently polyubiquitin phosphorylated at 'Ser-65'. Acts as negative regulator of mitochondrial fusion by mediating deubiquitination of MFN1 and MFN2.
Target Subcellular Location
Mitochondrion outer membrane.
Target Protein Families
Peptidase C19 family
Target Tissue Specificity
Expressed in skeletal muscle, pancreas, liver and kidney.
Target Synonyms
Deubiquitinating enzyme 30; FLJ40511; Ub-specific protease 30; Ubiquitin carboxyl terminal hydrolase 30; Ubiquitin carboxyl-terminal hydrolase 30; Ubiquitin specific peptidase 30; Ubiquitin specific processing protease 30; Ubiquitin thioesterase 30; Ubiquitin thiolesterase 30; Ubiquitin-specific-processing protease 30; UBP30_HUMAN; usp30
Target Background
USP30, a member of the ubiquitin-specific protease family (see USP1, MIM 603478), is a novel mitochondrial deubiquitinating (DUB) enzyme (Nakamura and Hirose, 2008 [PubMed 18287522]).
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