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The antibody against USP6 was raised in human using the Recombinant Human Ubiquitin carboxyl-terminal hydrolase 6 protein (348-535AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG1, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IF.
The antibody against USP6 was raised in human using the Recombinant Human Ubiquitin carboxyl-terminal hydrolase 6 protein (348-535AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG1, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IF.
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Western Blot Positive WB detected in: USP6 antibody at 1:1000 Lane 1: MCF-7 whole cell lysate Lane 2: THP-1 whole cell lysate Lane 3: SH-SY5Y whole cell lysate Lane 4: Jurkat whole cell lysate Lane 5: HEK293 whole cell lysate Lane 6: Hela whole cell lysateSecondary Goat polyclonal to Mouse IgG at 1/20000 dilution Predicted band size: 89, 122, 159 KDa Observed band size: 89, 122, 159 KDa Exposure time: 1min
| Cat.No | ADC-56055A | Clonality | Monoclonal |
|---|---|---|---|
| Host Species | Human | Target Name | USP6 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG1 | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, IF, WB | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Ubiquitin carboxyl-terminal hydrolase 6 protein (348-535AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P35125 |
Uniprot Id
P35125
Target Species
Human
Target Name
USP6
Target Full Name
Ubiquitin carboxyl-terminal hydrolase 6
Target Function
Deubiquitinase with an ATP-independent isopeptidase activity, cleaving at the C-terminus of the ubiquitin moiety. Catalyzes its own deubiquitination. In vitro, isoform 2, but not isoform 3, shows deubiquitinating activity. Promotes plasma membrane localization of ARF6 and selectively regulates ARF6-dependent endocytic protein trafficking. Is able to initiate tumorigenesis by inducing the production of matrix metalloproteinases following NF-kappa-B activation.
Target Involvement
A chromosomal aberration involving USP6 is a common genetic feature of aneurysmal bone cyst, a benign osseous neoplasm. Translocation t(16;17)(q22;p13) with CDH11. The translocation generates a fusion gene in which the strong CDH11 promoter is fused to the entire USP6 coding sequence, resulting in USP6 transcriptional up-regulation (PubMed:15026324).
Target Subcellular Location
Cell membrane. Cytoplasm. Endosome. Note=Localizes to the plasma membrane and to filamentous structures within the cell corresponding to ARF6 regulated tubular endosomes. Activation of RAC1 and CDC42 can direct the relocalization of USP6 to the plasma membrane in a manner that depends on the integrity of the actin cytoskeleton.
Target Protein Families
Peptidase C19 family
Target Tissue Specificity
Testis specific. Expressed in various cancer cell lines.
Target Research Area
Cell Biology
Target Synonyms
Deubiquitinating enzyme 6; HRP1; Proto-oncogene TRE-2; TRE17; TRE2; Ubiquitin carboxyl-terminal hydrolase 6; Ubiquitin specific protease 6; Ubiquitin thiolesterase 6; Ubiquitin-specific-processing protease 6; UBP6_HUMAN; USP6
Target Background
Enables thiol-dependent deubiquitinase. Involved in protein deubiquitination and regulation of vesicle-mediated transport. Located in plasma membrane and recycling endosome.
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