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The antibody against VANGL2 was raised in rabbit using the Recombinant Human Vang-like protein 2 protein (1-110AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB, IHC.
The antibody against VANGL2 was raised in rabbit using the Recombinant Human Vang-like protein 2 protein (1-110AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB, IHC.
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Immunohistochemistry of paraffin-embedded human lung cancer using VANGL2 Antibody at dilution of 1:1002
| Cat.No | ADC-16984A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | VANGL2 |
| Target Synonyms | VANGL2; KIAA1215; STB1; Vang-like protein 2; Loop-tail protein 1 homolog; Strabismus 1; Van Gogh-like protein 2 | Form | Liquid |
| Species Reactivity | Human, Mouse | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Antigen affinity purified |
| Conjugate | Non-conjugated | Application | ELISA, IHC, WB |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Vang-like protein 2 protein (1-110AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9ULK5 |
Uniprot Id
Q9ULK5
Target Species
Human
Target Name
VANGL2
Target Full Name
Vang-like protein 2
Target Function
Involved in the control of early morphogenesis and patterning of both axial midline structures and the development of neural plate. Plays a role in the regulation of planar cell polarity, particularly in the orientation of stereociliary bundles in the cochlea. Required for polarization and movement of myocardializing cells in the outflow tract and seems to act via RHOA signaling to regulate this process. Required for cell surface localization of FZD3 and FZD6 in the inner ear.
Target Involvement
Neural tube defects (NTD)
Target Subcellular Location
Cell membrane; Multi-pass membrane protein.
Target Protein Families
Vang family
Target Synonyms
VANGL2; KIAA1215; STB1; Vang-like protein 2; Loop-tail protein 1 homolog; Strabismus 1; Van Gogh-like protein 2
Target Background
The protein encoded by this gene is a membrane protein involved in the regulation of planar cell polarity, especially in the stereociliary bundles of the cochlea. The encoded protein transmits directional signals to individual cells or groups of cells in epithelial sheets. This protein is also involved in the development of the neural plate.
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