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The antibody against VAPB was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 10-222 of human VAPB (NP_004729.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, IF/ICC, ELISA.
The antibody against VAPB was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 10-222 of human VAPB (NP_004729.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, IF/ICC, ELISA.
| Cat.No | ADA-09705A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | VAPB |
| Target Synonyms | ALS8; VAP-B; VAMP-B; VAPB | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.05% proclin300, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Mouse kidney, Rat heart, Mouse brain, Mouse lung | Application | ELISA, WB, IF/ICC, IHC-P |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 10-222 of human VAPB (NP_004729.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | O95292 | Immunogen Sequence |
Uniprot Id
O95292
Target Species
Human
Target Name
VAPB
Target Full Name
Vesicle-associated membrane protein-associated protein B/C
Target Function
Participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity. Involved in cellular calcium homeostasis regulation.
Target Involvement
Amyotrophic lateral sclerosis 8 (ALS8); Spinal muscular atrophy, proximal, adult, autosomal dominant (SMAPAD)
Target Subcellular Location
Endoplasmic reticulum membrane; Single-pass type IV membrane protein.
Target Protein Families
VAMP-associated protein (VAP) (TC 9.B.17) family
Target Tissue Specificity
Ubiquitous. Isoform 1 predominates.
Target Synonyms
VAPB; UNQ484/PRO983; Vesicle-associated membrane protein-associated protein B/C; VAMP-B/VAMP-C; VAMP-associated protein B/C; VAP-B/VAP-C
Target Background
The protein encoded by this gene is a type IV membrane protein found in plasma and intracellular vesicle membranes. The encoded protein is found as a homodimer and as a heterodimer with VAPA. This protein also can interact with VAMP1 and VAMP2 and may be involved in vesicle trafficking.
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