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The antibody against VASH1 was raised in rabbit using the Human VASH1 as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB.
The antibody against VASH1 was raised in rabbit using the Human VASH1 as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB.
$600.00
| Cat.No | ADC-51385A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | VASH1 |
| Target Synonyms | KIAA1036 antibody; VASH antibody; VASH1 antibody; VASH1_HUMAN antibody; Vasohibin 1 antibody; Vasohibin-1 antibody | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, Avoid freeze / thaw cycles., PBS with 0.1% Sodium Azide | Purification Method | Antigen affinity purified |
| Conjugate | Non-conjugated | Application | ELISA, WB |
| Storage | Upon receipt |
| Immunogen Description | Human VASH1 | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q7L8A9 |
Uniprot Id
Q7L8A9
Target Species
Human
Target Name
VASH1
Target Full Name
Tubulinyl-Tyr carboxypeptidase 1
Target Function
Tyrosine carboxypeptidase that removes the C-terminal tyrosine residue of alpha-tubulin, thereby regulating microtubule dynamics and function. Critical for spindle function and accurate chromosome segregation during mitosis since microtuble detyronisation regulates mitotic spindle length and postioning. Acts as an angiogenesis inhibitor: inhibits migration, proliferation and network formation by endothelial cells as well as angiogenesis. This inhibitory effect is selective to endothelial cells as it does not affect the migration of smooth muscle cells or fibroblasts.
Target Subcellular Location
Cytoplasm. Secreted.
Target Protein Families
Vasohibin family
Target Tissue Specificity
Preferentially expressed in endothelial cells. Highly expressed in fetal organs. Expressed in brain and placenta, and at lower level in heart and kidney. Highly detected in microvessels endothelial cells of atherosclerotic lesions.
Target Research Area
Cardiovascular
Target Synonyms
KIAA1036; VASH; VASH1; VASH1_HUMAN; Vasohibin 1; Vasohibin-1
Target Background
Enables actin binding activity and metallocarboxypeptidase activity. Involved in negative regulation of angiogenesis; negative regulation of blood vessel endothelial cell migration; and proteolysis. Acts upstream of or within several processes, including negative regulation of endothelial cell migration; negative regulation of endothelial cell proliferation; and negative regulation of lymphangiogenesis. Located in apical part of cell; endoplasmic reticulum; and extracellular space. Implicated in liver cirrhosis and portal hypertension. Biomarker of liver cirrhosis.
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