Rabbit anti-Human VCPIP1 Polyclonal Antibody

Uniprot Id

Q96JH7

Target Species

Human

Target Name

VCPIP1

Target Full Name

Deubiquitinating protein VCPIP1

Target Function

Deubiquitinating enzyme involved in DNA repair and reassembly of the Golgi apparatus and the endoplasmic reticulum following mitosis. Necessary for VCP-mediated reassembly of Golgi stacks after mitosis. Plays a role in VCP-mediated formation of transitional endoplasmic reticulum (tER). Mediates dissociation of the ternary complex containing STX5A, NSFL1C and VCP. Also involved in DNA repair following phosphorylation by ATM or ATR: acts by catalyzing deubiquitination of SPRTN, thereby promoting SPRTN recruitment to chromatin and subsequent proteolytic cleavage of covalent DNA-protein cross-links (DPCs). Hydrolyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitin chains.; (Microbial infection) Regulates the duration of C.botulinum neurotoxin type A (BoNT/A) intoxication by catalyzing deubiquitination of Botulinum neurotoxin A light chain (LC), thereby preventing LC degradation by the proteasome, and accelerating botulinum neurotoxin intoxication in patients.

Target Subcellular Location

Nucleus. Cytoplasm. Endoplasmic reticulum. Golgi apparatus, Golgi stack.

Target Synonyms

Deubiquitinating protein VCIP135; DUBA3; KIAA1850; Valosin containing protein (p97)/p47 complex interacting protein 1; Valosin containing protein p97/p47 complex interacting protein 1; Valosin containing protein p97/p47 complex interacting protein p135; Valosin-containing protein p97/p47 complex-interacting protein 1; Valosin-containing protein p97/p47 complex-interacting protein p135; VCIP1_HUMAN; VCIP135; VCP/p47 complex-interacting 135-kDa protein; Vcpip1

Target Background

Enables thiol-dependent deubiquitinase. Involved in protein deubiquitination; protein-DNA covalent cross-linking repair; and regulation of protein localization to chromatin. Located in cytoplasm and nucleus.