Rabbit anti-Human Vinculin Monoclonal Antibody

The antibody against Vinculin was raised in Rabbit using a synthetic peptide corresponding to a sequence within amino acids 800-900 of human Vinculin (NP_054706.1) as the immunogen. The monoclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.

ADA-14925A

Number

Cat.No	ADA-14925A	Clonality	Monoclonal
Host Species	Rabbit	Target Name	Vinculin
Target Synonyms	MV; MVCL; CMD1W; CMH15; HEL114; Vinculin	Form	Liquid
Species Reactivity	Human, Mouse, Rat	Isotype	IgG
Storage Buffer	50% Glycerol, 0.05% BSA, PBS with 0.05% proclin300, pH7.3.	Purification Method	Affinity purification
Positive Samples	HeLa, Rat heart, Mouse brain, PC-12, Rat lung, RD	Application	ELISA, WB

Cat.No

ADA-14925A

Clonality

Monoclonal

Host Species

Rabbit

Target Name

Vinculin

Target Synonyms

MV; MVCL; CMD1W; CMH15; HEL114; Vinculin

Form

Liquid

Species Reactivity

Human, Mouse, Rat

Isotype

IgG

Storage Buffer

50% Glycerol, 0.05% BSA, PBS with 0.05% proclin300, pH7.3.

Purification Method

Affinity purification

Positive Samples

HeLa, Rat heart, Mouse brain, PC-12, Rat lung, RD

Application

ELISA, WB

Immunogen Description	A synthetic peptide corresponding to a sequence within amino acids 800-900 of human Vinculin (NP_054706.1).	Target Species	Human
Immunogen Sequence	DAKAVAGNISDPGLQKSFLDSGYRILGAVAKVREAFQPQEPDFPPPPPDLEQLRLTDELAPPKPPLPEGEVPPPRPPPPEEKDEEFPEQKAGEVINQPMMM	Uniprot ID	P18206

Immunogen Description

A synthetic peptide corresponding to a sequence within amino acids 800-900 of human Vinculin (NP_054706.1).

Target Species

Human

Immunogen Sequence

DAKAVAGNISDPGLQKSFLDSGYRILGAVAKVREAFQPQEPDFPPPPPDLEQLRLTDELAPPKPPLPEGEVPPPRPPPPEEKDEEFPEQKAGEVINQPMMM

Uniprot ID

P18206

Background Information

Uniprot Id

P18206
Target Species

Human
Target Name

VCL
Target Full Name

Vinculin
Target Function

Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion.
Target Involvement

Cardiomyopathy, dilated 1W (CMD1W); Cardiomyopathy, familial hypertrophic 15 (CMH15)
Target Subcellular Location

Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, adherens junction. Cell junction, focal adhesion. Cytoplasm, cytoskeleton. Cell membrane, sarcolemma; Peripheral membrane protein; Cytoplasmic side.
Target Protein Families

Vinculin/alpha-catenin family
Target Tissue Specificity

Metavinculin is muscle-specific.
Target Research Area

Cell Adhesion
Target Synonyms

CMD1W; CMH15; Epididymis luminal protein 114; HEL114; Metavinculin; MV; MVCL; OTTHUMP00000019861; OTTHUMP00000019862; VCL; VINC; VINC_HUMAN; Vinculin
Target Background

Vinculin is a cytoskeletal protein associated with cell-cell and cell-matrix junctions, where it is thought to function as one of several interacting proteins involved in anchoring F-actin to the membrane. Defects in VCL are the cause of cardiomyopathy dilated type 1W. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined.

Rabbit anti-Human Vinculin Monoclonal Antibody

Specifications

Immunogen Information

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