Rabbit anti-Human von Willebrand factor (VWF) Polyclonal Antibody

Uniprot Id

P04275

Target Species

Human

Target Name

VWF

Target Full Name

von Willebrand factor

Target Function

Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma.

Target Involvement

von Willebrand disease 1 (VWD1); von Willebrand disease 2 (VWD2); von Willebrand disease 3 (VWD3)

Target Subcellular Location

Secreted. Secreted, extracellular space, extracellular matrix. Note=Localized to storage granules.

Target Tissue Specificity

Plasma.

Target Synonyms

VWD; F8VWF; von Willebrand factor (VWF)

Target Background

This gene encodes a glycoprotein involved in hemostasis. The encoded preproprotein is proteolytically processed following assembly into large multimeric complexes. These complexes function in the adhesion of platelets to sites of vascular injury and the transport of various proteins in the blood. Mutations in this gene result in von Willebrand disease, an inherited bleeding disorder. An unprocessed pseudogene has been found on chromosome 22.