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The antibody against VPS51 was raised in rabbit using the Recombinant Human Vacuolar protein sorting-associated protein 51 homolog protein (595-673AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB.
The antibody against VPS51 was raised in rabbit using the Recombinant Human Vacuolar protein sorting-associated protein 51 homolog protein (595-673AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB.
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Western Blot | Positive WB detected in: Hela whole cell lysate, U251 whole cell lysate, A549 whole cell lysate, U87 whole cell lysate | All lanes: VPS51 antibody at 1:1000 | Secondary | Goat polyclonal to rabbit IgG at 1/50000 dilution | Predicted band size: 87, 73 kDa | Observed band size: 87 kDa
| Cat.No | ADC-02689A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | VPS51 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, WB | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Vacuolar protein sorting-associated protein 51 homolog protein (595-673AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9UID3 |
Uniprot Id
Q9UID3
Target Species
Human
Target Name
VPS51
Target Full Name
Vacuolar protein sorting-associated protein 51 homolog
Target Function
Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of protein retrieval from endosomes to the TGN, acid hydrolase sorting, lysosome function, endosomal cholesterol traffic and autophagy. VPS51 participates in retrograde transport of acid hydrolase receptors, likely by promoting tethering and SNARE-dependent fusion of endosome-derived carriers to the TGN. Acts as component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane.
Target Subcellular Location
Golgi apparatus, trans-Golgi network. Recycling endosome.
Target Protein Families
VPS51 family
Target Synonyms
ANG2; ANG3; Another new gene 2 protein; C11orf3; chromosome 11 open reading frame 2; Fat free homolog; ffr; FFR_HUMAN; FFR|FLJ13879; FLJ36472; Protein fat-free homolog; Vacuolar protein sorting 51 homolog; VPS51
Target Background
This gene encodes a member of the vacuolar protein sorting-associated protein 51 family. The encoded protein is a component of the Golgi-associated retrograde protein complex which acts as a tethering factor for carriers in retrograde transport from the early and late endosomes to the trans-Golgi network. Alternative splicing results in multiple transcript variants.
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