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The antibody against WEE2 was raised in rabbit using the Human WEE2 as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB.
The antibody against WEE2 was raised in rabbit using the Human WEE2 as the immunogen. This antibody exists as a non-conjugated isotype IgG, Antigen affinity purified. This antibody has been validated on ELISA, WB.
$600.00
| Cat.No | ADC-46701A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | WEE2 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 50% Glycerol, Avoid freeze / thaw cycles., 0.02% Sodium Azide, 0.1M Glycine, 0.1M NaHCO3 |
| Purification Method | Antigen affinity purified | Conjugate | Non-conjugated |
| Application | ELISA, WB | Storage | Upon receipt |
| Immunogen Description | Human WEE2 | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P0C1S8 |
Uniprot Id
P0C1S8
Target Species
Human
Target Name
WEE2
Target Full Name
Wee1-like protein kinase 2
Target Function
Oocyte-specific protein tyrosine kinase that phosphorylates and inhibits CDK1/CDC2 and acts as a key regulator of meiosis during both prophase I and metaphase II. Required to maintain meiotic arrest in oocytes during the germinal vesicle (GV) stage, a long period of quiescence at dictyate prophase I, by phosphorylating CDK1 at 'Tyr-15', leading to inhibit CDK1 activity and prevent meiotic reentry. Also required for metaphase II exit during egg activation by phosphorylating CDK1 at 'Tyr-15', to ensure exit from meiosis in oocytes and promote pronuclear formation.
Target Subcellular Location
Nucleus.
Target Protein Families
Protein kinase superfamily, Ser/Thr protein kinase family, WEE1 subfamily
Target Tissue Specificity
Expressed in oocytes (at protein level). May also be expressed in testis.
Target Synonyms
hCG_39453; WEE1 homolog 2 (S. pombe); Wee1-like protein kinase 1B; Wee1-like protein kinase 2; WEE1B; Wee1B kinase; Wee2; WEE2_HUMAN
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