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The antibody against WNT10A was raised in rabbit using the Recombinant Human Protein Wnt-10a protein (160-372AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
The antibody against WNT10A was raised in rabbit using the Recombinant Human Protein Wnt-10a protein (160-372AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IHC.
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Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using WNT10A Antibody at dilution of 1:100
| Cat.No | ADC-10048A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | WNT10A |
| Target Synonyms | FLJ14301 antibody; OODD antibody; Protein Wnt-10a antibody; SSPS antibody; STHAG4 antibody; Wingless type MMTV integration site family member 10A antibody; WN10A_HUMAN antibody; wnt10a antibody | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IHC |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human Protein Wnt-10a protein (160-372AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9GZT5 |
Uniprot Id
Q9GZT5
Target Species
Human
Target Name
WNT10A
Target Full Name
Protein Wnt-10a
Target Function
Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt/beta-catenin signaling pathway. Plays a role in normal ectoderm development. Required for normal tooth development. Required for normal postnatal development and maintenance of tongue papillae and sweat ducts. Required for normal proliferation of basal cells in tongue filiform papillae, plantar epithelium and sweat ducts. Required for normal expression of keratins in tongue papillae. Required for normal expression of KRT9 in foot plant epithelium. Required for normal hair follicle function.
Target Involvement
Odonto-onycho-dermal dysplasia (OODD); Schopf-Schulz-Passarge syndrome (SSPS); Tooth agenesis, selective, 4 (STHAG4)
Target Subcellular Location
Secreted, extracellular space, extracellular matrix. Secreted.
Target Protein Families
Wnt family
Target Research Area
Cancer
Target Synonyms
FLJ14301; OODD; Protein Wnt-10a; SSPS; STHAG4; Wingless type MMTV integration site family member 10A; WN10A_HUMAN; wnt10a
Target Background
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is strongly expressed in the cell lines of promyelocytic leukemia and Burkitt's lymphoma. In addition, it and another family member, the WNT6 gene, are strongly coexpressed in colorectal cancer cell lines. The gene overexpression may play key roles in carcinogenesis through activation of the WNT-beta-catenin-TCF signaling pathway. This gene and the WNT6 gene are clustered in the chromosome 2q35 region.
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