Rabbit anti-Human XRCC1 Monoclonal Antibody

The antibody against XRCC1 was raised in Rabbit using a synthetic peptide corresponding to a sequence within amino acids 1-100 of human XRCC1 (P18887) as the immunogen. The monoclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.

ADA-13831A

Number

Cat.No	ADA-13831A	Clonality	Monoclonal
Host Species	Rabbit	Target Name	XRCC1
Target Synonyms	RCC; SCAR26; XRCC1	Form	Liquid
Species Reactivity	Human, Mouse, Rat	Isotype	IgG
Storage Buffer	50% Glycerol, 0.05% BSA, PBS with 0.02% sodium azide, pH7.3.	Purification Method	Affinity purification
Positive Samples	K-562, Mouse testis, Rat testis	Application	ELISA, WB

Cat.No

ADA-13831A

Clonality

Monoclonal

Host Species

Rabbit

Target Name

XRCC1

Target Synonyms

RCC; SCAR26; XRCC1

Form

Liquid

Species Reactivity

Human, Mouse, Rat

Isotype

IgG

Storage Buffer

50% Glycerol, 0.05% BSA, PBS with 0.02% sodium azide, pH7.3.

Purification Method

Affinity purification

Positive Samples

K-562, Mouse testis, Rat testis

Application

ELISA, WB

Immunogen Description	A synthetic peptide corresponding to a sequence within amino acids 1-100 of human XRCC1 (P18887).	Target Species	Human
Immunogen Sequence	MPEIRLRHVVSCSSQDSTHCAENLLKADTYRKWRAAKAGEKTISVVLQLEKEEQIHSVDIGNDGSAFVEVLVGSSAGGAGEQDYEVLLVTSSFMSPSESR	Uniprot ID	P18887

Immunogen Description

A synthetic peptide corresponding to a sequence within amino acids 1-100 of human XRCC1 (P18887).

Target Species

Human

Immunogen Sequence

MPEIRLRHVVSCSSQDSTHCAENLLKADTYRKWRAAKAGEKTISVVLQLEKEEQIHSVDIGNDGSAFVEVLVGSSAGGAGEQDYEVLLVTSSFMSPSESR

Uniprot ID

P18887

Background Information

Uniprot Id

P18887
Target Species

Human
Target Name

XRCC1
Target Full Name

DNA repair protein XRCC1
Target Function

Involved in DNA single-strand break repair by mediating the assembly of DNA break repair protein complexes. Probably during DNA repair, negatively regulates ADP-ribose levels by modulating ADP-ribosyltransferase PARP1 activity.
Target Involvement

Spinocerebellar ataxia, autosomal recessive, 26 (SCAR26)
Target Subcellular Location

Nucleus.
Target Tissue Specificity

Expressed in fibroblasts, retinal pigmented epithelial cells and lymphoblastoid cells (at protein level).
Target Synonyms

DNA repair protein XRCC1; RCC; X ray repair complementing defective repair in chinese hamster; X ray Repair Complementing Defective Repair in Chinese Hamster Cells; X ray repair complementing defective repair in chinese hamster cells 1; X ray repair cross complementing 1; X ray repair cross complementing protein 1; X ray repair; complementing defective; repair in Chinese hamster; X-ray repair cross-complementing protein 1; XRCC 1; Xrcc1; XRCC1_HUMAN
Target Background

The protein encoded by this gene is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents. This protein interacts with DNA ligase III, polymerase beta and poly (ADP-ribose) polymerase to participate in the base excision repair pathway. It may play a role in DNA processing during meiogenesis and recombination in germ cells. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity.

Rabbit anti-Human XRCC1 Monoclonal Antibody

Specifications

Immunogen Information

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