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The antibody against ZBED1 was raised in rabbit using the Recombinant Human Zinc finger BED domain-containing protein 1 protein (1-210AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC.
The antibody against ZBED1 was raised in rabbit using the Recombinant Human Zinc finger BED domain-containing protein 1 protein (1-210AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC.
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Immunohistochemistry of paraffin-embedded human placenta tissue using ZBED1 Antibody at dilution of 1:1002
| Cat.No | ADC-50453A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | ZBED1 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, IHC, WB | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Zinc finger BED domain-containing protein 1 protein (1-210AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | O96006 |
Uniprot Id
O96006
Target Species
Human
Target Name
ZBED1
Target Full Name
E3 SUMO-protein ligase ZBED1
Target Function
Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase which sumoylates CHD3/Mi2-alpha, causing its release from DNA. This results in suppression of CHD3/Mi2-alpha transcription repression, increased recruitment of RNA polymerase II to gene promoters and positive regulation of transcription including H1-5 and ribosomal proteins such as: RPS6, RPL10A, and RPL12. The resulting increased transcriptional activity drives cell proliferation. Binds to 5'-TGTCG[CT]GA[CT]A-3' consensus sequences in gene promoters of ribosomal proteins.; (Microbial infection) Binds to human adenovirus gene promoters and contributes to transcriptional repression and virus growth inhibition during early stages of infection.
Target Subcellular Location
Nucleus, PML body. Nucleus.; Nucleus, PML body.
Target Tissue Specificity
Ubiquitously expressed at low levels. Expression is highest in skeletal muscle, heart, spleen and placenta.
Target Research Area
Epigenetics and Nuclear Signaling
Target Synonyms
Ac like transposable element; ALTE; BED type zinc finger domain containing protein 1; DNA replication related element binding factor; dREF homolog; hDREF; KIAA0785; Putative Ac like transposon; Putative Ac-like transposable element; TRAMP; ZBED1; ZBED1_HUMAN; Zinc finger BED domain-containing protein 1; Zinc finger BED type containing 1
Target Background
This gene is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes. It was earlier identified as a gene with similarity to Ac transposable elements, however, was found not to have transposase activity. Later studies show that this gene product is localized in the nucleus and functions as a transcription factor. It binds to DNA elements found in the promoter regions of several genes related to cell proliferation, such as histone H1, hence may have a role in regulating genes related to cell proliferation. Alternatively spliced transcript variants with different 5' untranslated region have been found for this gene.
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