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The antibody against ZBTB18 was raised in rabbit using the Recombinant Human Zinc finger and BTB domain-containing protein 18 protein (62-364AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC.
The antibody against ZBTB18 was raised in rabbit using the Recombinant Human Zinc finger and BTB domain-containing protein 18 protein (62-364AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, WB, IHC.
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Immunohistochemistry of paraffin-embedded human tonsil tissue using ZBTB18 Antibody at dilution of 1:1002
| Cat.No | ADC-22922A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | ZBTB18 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | Non-conjugated |
| Application | ELISA, IHC, WB | Storage | Upon receipt |
| Immunogen Description | Recombinant Human Zinc finger and BTB domain-containing protein 18 protein (62-364AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q99592 |
Uniprot Id
Q99592
Target Species
Human
Target Name
ZBTB18
Target Full Name
Zinc finger and BTB domain-containing protein 18
Target Function
Transcriptional repressor that plays a role in various developmental processes such as myogenesis and brain development. Plays a key role in myogenesis by directly repressing the expression of ID2 and ID3, 2 inhibitors of skeletal myogenesis. Also involved in controlling cell division of progenitor cells and regulating the survival of postmitotic cortical neurons. Specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. May also play a role in the organization of chromosomes in the nucleus.
Target Involvement
Mental retardation, autosomal dominant 22 (MRD22)
Target Subcellular Location
Nucleus. Note=Associates with condensed chromatin.
Target Protein Families
Krueppel C2H2-type zinc-finger protein family, ZBTB18 subfamily
Target Tissue Specificity
Lymphoid tissues, testis, heart, brain, skeletal muscle, and pancreas and, at much lower level, other tissues.
Target Synonyms
C2H2171; 58 kDa repressor protein; C2H2 171; RP58; TAZ 1; TAZ-1; TAZ1; Transcriptional repressor RP58; Translin associated zinc finger protein 1; Translin-associated zinc finger protein 1; ZBTB18; Zinc finger and BTB domain containing protein 18; Zinc finger and BTB domain-containing protein 18; Zinc finger protein 238; Zinc finger protein C2H2 171; Zinc finger protein C2H2-171; ZN238_HUMAN; ZNF238
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