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The antibody against ZCWPW1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 389-648 of human ZCWPW1 (NP_060454.3) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against ZCWPW1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 389-648 of human ZCWPW1 (NP_060454.3) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-09305A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | ZCWPW1 |
| Target Synonyms | ZCW1; ZCWPW1 | Form | Liquid |
| Species Reactivity | Human, Mouse | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Mouse testis, OVCAR3, SKOV3 | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 389-648 of human ZCWPW1 (NP_060454.3). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q9H0M4 | Immunogen Sequence |
Uniprot Id
Q9H0M4
Target Species
Human
Target Name
ZCWPW1
Target Full Name
Zinc finger CW-type PWWP domain protein 1
Target Function
Dual histone methylation reader specific for PRDM9-catalyzed histone marks (H3K4me3 and H3K36me3). Facilitates the repair of PRDM9-induced meiotic double-strand breaks (DSBs). Essential for male fertility and spermatogenesis. Required for meiosis prophase I progression in male but not in female germ cells.
Target Subcellular Location
Nucleus. Chromosome.
Target Tissue Specificity
Testis.
Target Synonyms
ZCWPW1Zinc finger CW-type PWWP domain protein 1
Target Background
Enables methyl-CpG binding activity and methylated histone binding activity. Predicted to be involved in meiosis I; positive regulation of DNA metabolic process; and spermatogenesis. Predicted to act upstream of or within homologous chromosome pairing at meiosis. Predicted to be located in XY body. Predicted to be active in nucleus.
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