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The antibody against ZFYVE1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 500-735 of human ZFYVE1 (NP_067083.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against ZFYVE1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 500-735 of human ZFYVE1 (NP_067083.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-12442A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | ZFYVE1 |
| Target Synonyms | SR3; DFCP1; TAFF1; ZNFN2A1; PPP1R172; ZFYVE1 | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | 293T | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 500-735 of human ZFYVE1 (NP_067083.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q9HBF4 | Immunogen Sequence |
Uniprot Id
Q9HBF4
Target Species
Human
Target Name
ZFYVE1
Target Full Name
Zinc finger FYVE domain-containing protein 1
Target Function
Plays a role in the formation of lipid droplets (LDs) which are storage organelles at the center of lipid and energy homeostasis. Regulates the morphology, size and distribution of LDs. Mediates the formation of endoplasmic reticulum-lipid droplets (ER-LD) contacts by forming a complex with RAB18 and ZW10. Binds to phosphatidylinositol 3-phosphate (PtdIns3P) through FYVE-type zinc finger.
Target Subcellular Location
Golgi apparatus, Golgi stack. Golgi apparatus. Endoplasmic reticulum. Lipid droplet. Preautophagosomal structure. Mitochondrion.
Target Tissue Specificity
[Isoform 2]: Highly expressed in heart. Also detected in the testis.; [Isoform 1]: Expressed in all tissues examined, including, brain, placenta, lung, liver, skeletal muscle, pancreas and kidney. Highly expressed in heart.
Target Synonyms
ZFYVE1; DFCP1; KIAA1589; TAFF1; ZNFN2A1; PP10436Zinc finger FYVE domain-containing protein 1; Double FYVE-containing protein 1; SR3; Tandem FYVE fingers-1
Target Background
The FYVE domain mediates the recruitment of proteins involved in membrane trafficking and cell signaling to phosphatidylinositol 3-phosphate-containing membranes. This protein contains two zinc-binding FYVE domains in tandem and is reported to localize to the Golgi apparatus. Alternative splicing results in multiple transcript variants.
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