Rabbit anti-Human ZFYVE9 Polyclonal Antibody

The antibody against ZFYVE9 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human ZFYVE9 (NP_004790.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.

ADA-01058A

Number

Cat.No	ADA-01058A	Clonality	Polyclonal
Host Species	Rabbit	Target Name	ZFYVE9
Target Synonyms	NSP; SARA; MADHIP; SMADIP; PPP1R173; ZFYVE9	Form	Liquid
Species Reactivity	Human	Isotype	IgG
Storage Buffer	50% Glycerol, PBS with 0.02% sodium azide, pH7.3.	Purification Method	Affinity purification
Positive Samples	HeLa, LO2	Application	ELISA, WB

Cat.No

ADA-01058A

Clonality

Polyclonal

Host Species

Rabbit

Target Name

ZFYVE9

Target Synonyms

NSP; SARA; MADHIP; SMADIP; PPP1R173; ZFYVE9

Form

Liquid

Species Reactivity

Human

Isotype

IgG

Storage Buffer

50% Glycerol, PBS with 0.02% sodium azide, pH7.3.

Purification Method

Affinity purification

Positive Samples

HeLa, LO2

Application

ELISA, WB

Immunogen Description	Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human ZFYVE9 (NP_004790.2).	Target Species	Human
Uniprot ID	O95405	Immunogen Sequence

Immunogen Description

Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human ZFYVE9 (NP_004790.2).

Target Species

Human

Uniprot ID

O95405

Immunogen Sequence

Background Information

Uniprot Id

O95405
Target Species

Human
Target Name

ZFYVE9
Target Full Name

Zinc finger FYVE domain-containing protein 9
Target Function

Early endosomal protein that functions to recruit SMAD2/SMAD3 to intracellular membranes and to the TGF-beta receptor. Plays a significant role in TGF-mediated signaling by regulating the subcellular location of SMAD2 and SMAD3 and modulating the transcriptional activity of the SMAD3/SMAD4 complex. Possibly associated with TGF-beta receptor internalization.
Target Subcellular Location

Cytoplasm. Early endosome membrane.
Target Tissue Specificity

Ubiquitous. In the brain found primarily in the cerebrovascular smooth muscle cells and reactive astrocytes.
Target Synonyms

CG15667; hSARA; LD33044p; Madh-interacting protein; MADHIP; Mothers against decapentaplegic homolog-interacting protein; Novel serine protease; NSP; Receptor activation anchor; SAR1; SARA; SARA1; Smad anchor for receptor activation; SMADIP; ZFYV9_HUMAN; ZFYVE9; Zinc finger FYVE domain-containing protein 9
Target Background

This gene encodes a double zinc finger motif-containing protein that participates in the transforming growth factor-beta (TGFB) signalling pathway. The encoded protein interacts directly with SMAD2 and SMAD3, and recruits SMAD2 to the TGFB receptor. There are multiple pseudogenes for this gene on chromosomes 2, 15, and X. Alternative splicing results in multiple transcript variants.

Rabbit anti-Human ZFYVE9 Polyclonal Antibody

Specifications

Immunogen Information

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