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The antibody against ZMYND11 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 278-567 of human ZMYND11 (NP_997644.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against ZMYND11 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 278-567 of human ZMYND11 (NP_997644.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-03087A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | ZMYND11 |
| Target Synonyms | BS69; BRAM1; MRD30; ZMYND11 | Form | Liquid |
| Species Reactivity | Human, Mouse | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Mouse kidney, Jurkat, Mouse brain, Mouse lung, SW620, U-937 | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 278-567 of human ZMYND11 (NP_997644.2). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q15326 | Immunogen Sequence |
Uniprot Id
Q15326
Target Species
Human
Target Name
ZMYND11
Target Full Name
Zinc finger MYND domain-containing protein 11
Target Function
Chromatin reader that specifically recognizes and binds histone H3.3 trimethylated at 'Lys-36' (H3.3K36me3) and regulates RNA polymerase II elongation. Does not bind other histone H3 subtypes (H3.1 or H3.2). Colocalizes with highly expressed genes and functions as a transcription corepressor by modulating RNA polymerase II at the elongation stage. Binds non-specifically to dsDNA. Acts as a tumor-suppressor by repressing a transcriptional program essential for tumor cell growth.; (Microbial infection) Inhibits Epstein-Barr virus EBNA2-mediated transcriptional activation and host cell proliferation, through direct interaction.
Target Involvement
Mental retardation, autosomal dominant 30 (MRD30)
Target Subcellular Location
Nucleus. Chromosome.
Target Tissue Specificity
Ubiquitous.
Target Synonyms
ZMYND11; BRAM1; BS69; Zinc finger MYND domain-containing protein 11; Adenovirus 5 E1A-binding protein; Bone morphogenetic protein receptor-associated molecule 1; Protein BS69
Target Background
The protein encoded by this gene was first identified by its ability to bind the adenovirus E1A protein. The protein localizes to the nucleus. It functions as a transcriptional repressor, and expression of E1A inhibits this repression. Alternatively spliced transcript variants encoding different isoforms have been identified.
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