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The antibody against ZNF207 was raised in rabbit using the Recombinant Human BUB3-interacting and GLEBS motif-containing protein ZNF207 protein (206-463AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IF.
The antibody against ZNF207 was raised in rabbit using the Recombinant Human BUB3-interacting and GLEBS motif-containing protein ZNF207 protein (206-463AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA, IF.
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Immunofluorescent analysis of Hela cells using ZNF207 Antibody at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
| Cat.No | ADC-10684A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | ZNF207 |
| Target Synonyms | Zinc finger protein 207 antibody; ZN207_HUMAN antibody; ZNF 207 antibody; ZNF207 antibody | Form | Liquid |
| Species Reactivity | Human | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, IF |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Human BUB3-interacting and GLEBS motif-containing protein ZNF207 protein (206-463AA) | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | O43670 |
Uniprot Id
O43670
Target Species
Human
Target Name
ZNF207
Target Full Name
BUB3-interacting and GLEBS motif-containing protein ZNF207
Target Function
Kinetochore- and microtubule-binding protein that plays a key role in spindle assembly. ZNF207/BuGZ is mainly composed of disordered low-complexity regions and undergoes phase transition or coacervation to form temperature-dependent liquid droplets. Coacervation promotes microtubule bundling and concentrates tubulin, promoting microtubule polymerization and assembly of spindle and spindle matrix by concentrating its building blocks. Also acts as a regulator of mitotic chromosome alignment by mediating the stability and kinetochore loading of BUB3. Mechanisms by which BUB3 is protected are unclear: according to a first report, ZNF207/BuGZ may act by blocking ubiquitination and proteasomal degradation of BUB3. According to another report, the stabilization is independent of the proteasome.
Target Subcellular Location
Nucleus. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle.
Target Tissue Specificity
Ubiquitous.
Target Synonyms
Zinc finger protein 207; ZN207_HUMAN; ZNF 207; ZNF207
Target Background
Enables microtubule binding activity. Involved in several processes, including mitotic nuclear division; mitotic spindle assembly checkpoint signaling; and protein stabilization. Located in kinetochore; nuclear lumen; and spindle matrix.
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