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The antibody against ZNF451 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 600-900 of human ZNF451 (NP_001026794.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against ZNF451 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 600-900 of human ZNF451 (NP_001026794.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-05071A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | ZNF451 |
| Target Synonyms | ZATT; COASTER; dJ417I1.1; ZNF451 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 600-900 of human ZNF451 (NP_001026794.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q9Y4E5 | Immunogen Sequence |
Uniprot Id
Q9Y4E5
Target Species
Human
Target Name
ZNF451
Target Full Name
E3 SUMO-protein ligase ZNF451
Target Function
E3 SUMO-protein ligase; has a preference for SUMO2 and SUMO3 and facilitates UBE2I/UBC9-mediated sumoylation of target proteins. Plays a role in protein SUMO2 modification in response to stress caused by DNA damage and by proteasome inhibitors (in vitro). Required for MCM4 sumoylation. Has no activity with SUMO1. Preferentially transfers an additional SUMO2 chain onto the SUMO2 consensus site 'Lys-11'. Negatively regulates transcriptional activation mediated by the SMAD4 complex in response to TGF-beta signaling. Inhibits EP300-mediated acetylation of histone H3 at 'Lys-9'. Plays a role in regulating the transcription of AR targets
Target Subcellular Location
Nucleus. Nucleus, PML body. Nucleus, nucleoplasm.
Target Protein Families
Krueppel C2H2-type zinc-finger protein family
Target Synonyms
Coactivator for steroid receptors; COASTER; dJ417I1.1; E3 SUMO-protein ligase ZNF451; OTTHUMP00000218171; Zinc finger protein 451; ZN451_HUMAN; Znf451
Target Background
Enables SUMO ligase activity and transcription corepressor activity. Involved in negative regulation of nitrogen compound metabolic process; negative regulation of transforming growth factor beta receptor signaling pathway; and protein sumoylation. Located in nucleus.
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