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The antibody against ZWILCH was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 292-591 of human ZWILCH (NP_060445.3) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against ZWILCH was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 292-591 of human ZWILCH (NP_060445.3) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-05531A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | ZWILCH |
| Target Synonyms | KNTC1AP; hZwilch; ZWILCH | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | HeLa, Rat brain, DU145, MCF7, Mouse brain, Mouse testis, PC-12 | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 292-591 of human ZWILCH (NP_060445.3). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | Q9H900 | Immunogen Sequence |
Uniprot Id
Q9H900
Target Species
Human
Target Name
ZWILCH
Target Full Name
Protein zwilch homolog
Target Function
Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex.
Target Subcellular Location
Chromosome, centromere, kinetochore.
Target Protein Families
ZWILCH family
Target Synonyms
FLJ10036; FLJ16343; homolog of Drosophila Zwilch; hZwilch; KNTC1AP; MGC111034; Protein zwilch homolog; ZWILC_HUMAN; zwilch; zwilch kinetochore protein; ZWILCH protein; Zwilch, kinetochore associated, homolog
Target Background
Involved in protein localization to kinetochore. Located in kinetochore. Part of RZZ complex.
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