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The antibody against ZWINT was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-277 of human ZWINT (NP_008988.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
The antibody against ZWINT was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-277 of human ZWINT (NP_008988.2) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
| Cat.No | ADA-03084A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | ZWINT |
| Target Synonyms | SIP30; ZWINT1; KNTC2AP; HZwint-1; ZWINT | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | 293T, HepG2, Jurkat, Mouse brain, SW620 | Application | ELISA, WB, IF/ICC |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-277 of human ZWINT (NP_008988.2). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | O95229 | Immunogen Sequence |
Uniprot Id
O95229
Target Species
Human
Target Name
ZWINT
Target Full Name
Outer kinetochore KNL1 complex subunit ZWINT
Target Function
Part of the MIS12 complex, which is required for kinetochore formation and spindle checkpoint activity. Required to target ZW10 to the kinetochore at prometaphase.
Target Subcellular Location
Nucleus. Chromosome, centromere, kinetochore. Note=Localizes to kinetochores from late prophase to anaphase.
Target Research Area
Cell Biology
Target Synonyms
Human ZW10 interacting protein 1; HZwint 1; HZwint1; KNTC 2 AP; KNTC2AP; MGC 117174; MGC117174; ZW10 interacting kinetochore protein; ZW10 interacting protein 1; ZW10 interactor; ZW10 interactor; kinetochore protein; ZW10-interacting protein 1; ZWINT 1; ZWINT; Zwint-1; ZWINT_HUMAN; ZWINT1
Target Background
This gene encodes a protein that is clearly involved in kinetochore function although an exact role is not known. It interacts with ZW10, another kinetochore protein, possibly regulating the association between ZW10 and kinetochores. The encoded protein localizes to prophase kinetochores before ZW10 does and it remains detectable on the kinetochore until late anaphase. It has a uniform distribution in the cytoplasm of interphase cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
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