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The antibody against NP was raised in rabbit using the Recombinant Influenza B virus Nucleoprotein protein (1-168AA) as the immunogen. This antibody exists as a biotin conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.
The antibody against NP was raised in rabbit using the Recombinant Influenza B virus Nucleoprotein protein (1-168AA) as the immunogen. This antibody exists as a biotin conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.
$299.00
| Cat.No | ADC-49868A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | NP |
| Target Synonyms | NPNucleoprotein antibody; Nucleocapsid protein antibody; Protein N antibody | Form | Liquid |
| Species Reactivity | Influenza B virus | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Biotin conjugated | Application | ELISA |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Influenza B virus Nucleoprotein protein (1-168AA) | Target Species | Influenza B virus |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P04666 |
Uniprot Id
P04666
Target Species
Influenza B virus
Target Name
NP
Target Function
Encapsidates the negative strand viral RNA, protecting it from nucleases. The encapsidated genomic RNA is termed the ribonucleoprotein (RNP) and serves as template for transcription and replication. The RNP needs to be localized in the host nucleus to start an infectious cycle, but is too large to diffuse through the nuclear pore complex. NP comprises at least 2 nuclear localization signals that are responsible for the active RNP import into the nucleus through cellular importin alpha/beta pathway. Later in the infection, nclear export of RNPs are mediated through viral proteins NEP interacting with M1 which binds nucleoproteins. It is possible that nucleoprotein binds directly host exportin-1/XPO1 and plays an active role in RNPs nuclear export. M1 interaction with RNP seems to hide nucleoprotein's nuclear localization signals. Soon after a virion infects a new cell, M1 dissociates from the RNP under acidification of the virion driven by M2 protein. Dissociation of M1 from RNP unmasks nucleoprotein's nuclear localization signals, targeting the RNP to the nucleus.
Target Subcellular Location
Virion. Host nucleus.
Target Protein Families
Influenza viruses nucleoprotein family
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