ITK Recombinant Monoclonal Antibody

Uniprot Id

Q08881

Target Species

Human

Target Name

ITK

Target Full Name

Tyrosine-protein kinase ITK/TSK

Target Function

Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation lead to the recruitment of ITK to the cell membrane, in the vicinity of the stimulated TCR receptor, where it is phosphorylated by LCK. Phosphorylation leads to ITK autophosphorylation and full activation. Once activated, phosphorylates PLCG1, leading to the activation of this lipase and subsequent cleavage of its substrates. In turn, the endoplasmic reticulum releases calcium in the cytoplasm and the nuclear activator of activated T-cells (NFAT) translocates into the nucleus to perform its transcriptional duty. Phosphorylates 2 essential adapter proteins: the linker for activation of T-cells/LAT protein and LCP2. Then, a large number of signaling molecules such as VAV1 are recruited and ultimately lead to lymphokine production, T-cell proliferation and differentiation. Required for TCR-mediated calcium response in gamma-delta T-cells, may also be involved in the modulation of the transcriptomic signature in the Vgamma2-positive subset of immature gamma-delta T-cells. Phosphorylates TBX21 at 'Tyr-530' and mediates its interaction with GATA3.

Target Involvement

Lymphoproliferative syndrome 1 (LPFS1)

Target Subcellular Location

Cytoplasm. Nucleus. Note=Localizes in the vicinity of cell surface receptors in the plasma membrane after receptor stimulation.

Target Protein Families

Protein kinase superfamily, Tyr protein kinase family, TEC subfamily

Target Tissue Specificity

T-cell lines and natural killer cell lines.

Target Synonyms

EMT; Homolog of mouse T cell itk/tsk; IL 2 inducible T cell kinase; IL2 inducible T cell kinase; Interleukin 2 inducible T cell kinase; Itk; ITK_HUMAN; Kinase EMT; LPFS1; LYK; MGC126257; MGC126258; PSCTK 2; PSCTK2; T cell specific kinase; T-cell-specific kinase; TSK; Tyrosine protein kinase; Tyrosine protein kinase ITK/TSK; Tyrosine protein kinase Lyk; Tyrosine-protein kinase ITK/TSK; Tyrosine-protein kinase Lyk

Target Background

This gene encodes an intracellular tyrosine kinase expressed in T-cells. The protein contains both SH2 and SH3 domains which are often found in intracellular kinases. It is thought to play a role in T-cell proliferation and differentiation.