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The recombinant antibody against LIG1 was produced using a synthesized peptide derived from human DNA Ligase I as the immunogen. This antibody exists as a non-conjugated isotype Rabbit IgG, Affinity-chromatography purified. This antibody has been validated on ELISA, WB, IHC.
The recombinant antibody against LIG1 was produced using a synthesized peptide derived from human DNA Ligase I as the immunogen. This antibody exists as a non-conjugated isotype Rabbit IgG, Affinity-chromatography purified. This antibody has been validated on ELISA, WB, IHC.
$350.00
Western Blot | Positive WB detected in: Hela whole cell lysate, HepG2 whole cell lysate | All lanes: DNA Ligase I antibody at 1:1000 | Secondary | Goat polyclonal to rabbit IgG at 1/50000 dilution | Predicted band size: 102, 89, 99 kDa | Observed band size: 140 kDa
| Cat.No | ADC-56812A | Clonality | Monoclonal |
|---|---|---|---|
| Target Name | LIG1 | Target Synonyms | DNA ligase 1 (EC 6.5.1.1) (DNA ligase I) (Polydeoxyribonucleotide synthase [ATP] 1), LIG1 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | Rabbit IgG | Storage Buffer | PH 7.4, 0.02% sodium azide and 50% glycerol., 150mM NaCl, Rabbit IgG in phosphate buffered saline |
| Purification Method | Affinity-chromatography purified | Conjugate | Non-conjugated |
| Application | ELISA, IHC, WB | Storage | Upon receipt |
| Immunogen Description | A synthesized peptide derived from human DNA Ligase I | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P18858 |
Uniprot Id
P18858
Target Species
Human
Target Name
LIG1
Target Full Name
DNA ligase 1
Target Function
DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.
Target Subcellular Location
Nucleus.
Target Protein Families
ATP-dependent DNA ligase family
Target Research Area
Cell Cycle
Target Synonyms
DNA ligase 1; DNA ligase I; DNLI1_HUMAN; LIG 1; lig1; Ligase I DNA ATP dependent; MGC117397; MGC130025; Polydeoxyribonucleotide synthase [ATP] 1
Target Background
This gene encodes a member of the ATP-dependent DNA ligase protein family. The encoded protein functions in DNA replication, recombination, and the base excision repair process. Mutations in this gene that lead to DNA ligase I deficiency result in immunodeficiency and increased sensitivity to DNA-damaging agents. Disruption of this gene may also be associated with a variety of cancers. Alternative splicing results in multiple transcript variants.
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