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The antibody against GPC was raised in rabbit using the Recombinant Lymphocytic choriomeningitis virus Pre-glycoprotein polyprotein GP complex protein (266-498AA) as the immunogen. This antibody exists as a biotin conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.
The antibody against GPC was raised in rabbit using the Recombinant Lymphocytic choriomeningitis virus Pre-glycoprotein polyprotein GP complex protein (266-498AA) as the immunogen. This antibody exists as a biotin conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.
$299.00
| Cat.No | ADC-20510A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | GPC |
| Target Synonyms | GPC; GP-C; Segment; S; Pre-glycoprotein polyprotein GP complex; Pre-GP-C | Form | Liquid |
| Species Reactivity | Lymphocytic choriomeningitis virus | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Biotin conjugated | Application | ELISA |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Lymphocytic choriomeningitis virus Pre-glycoprotein polyprotein GP complex protein (266-498AA) | Target Species | Lymphocytic choriomeningitis virus (strain Armstrong) (LCMV) |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P09991 |
Uniprot Id
P09991
Target Species
Lymphocytic choriomeningitis virus
Target Name
GPC
Target Function
class I viral fusion protein that directs fusion of viral and host endosomal membranes, leading to delivery of the nucleocapsid into the cytoplasm. Membrane fusion is mediated by irreversible conformational changes induced upon acidification in the endosome.; Stable signal peptide (SSP): cleaved and functions as a signal peptide. In addition, it is also retained as the third component of the GP complex. The SSP is required for efficient glycoprotein expression, post-translational maturation cleavage of GP1 and GP2, glycoprotein transport to the cell surface plasma membrane, formation of infectious virus particles, and acid pH-dependent glycoprotein-mediated cell fusion.; interacts with the host receptor. Mediates virus attachment to host receptor alpha-dystroglycan DAG1. This attachment induces virion internalization predominantly through clathrin- and caveolin-independent endocytosis.
Target Subcellular Location
[Glycoprotein G1]: Virion membrane; Peripheral membrane protein. Host endoplasmic reticulum membrane; Peripheral membrane protein. Host Golgi apparatus membrane; Peripheral membrane protein. Host cell membrane; Peripheral membrane protein.; [Glycoprotein G2]: Virion membrane; Single-pass membrane protein. Host endoplasmic reticulum membrane; Single-pass membrane protein. Host Golgi apparatus membrane; Single-pass membrane protein. Host cell membrane; Single-pass membrane protein.; [Stable signal peptide]: Virion membrane; Multi-pass membrane protein. Host endoplasmic reticulum membrane; Multi-pass membrane protein. Host Golgi apparatus membrane; Multi-pass membrane protein. Host cell membrane; Multi-pass membrane protein.
Target Protein Families
Arenaviridae GPC protein family
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