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The antibody against CD274 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 19-239 of mouse CD274 (NP_068693.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against CD274 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 19-239 of mouse CD274 (NP_068693.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-14390A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | CD274 |
| Target Synonyms | B7h1; Pdl1; Pdcd1l1; Pdcd1lg1; A530045L16Rik; 74 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.05% proclin300, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | A-549, Mouse skeletal muscle, Rat skeletal muscle | Application | ELISA, WB |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 19-239 of mouse CD274 (NP_068693.1). | Target Species | Mouse |
|---|---|---|---|
| Uniprot ID | Q9EP73 | Immunogen Sequence |
Uniprot Id
Q9EP73
Target Synonyms
B7h1; Pdl1; Pdcd1l1; Pdcd1lg1; A530045L16Rik; 74
Target Background
The protein encoded by this gene is an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Mice deficient for this gene display a variety of phenotypes including decreased allogeneic fetal survival rates and severe experimental autoimmune encephalomyelitis.
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