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The antibody against HIST1H3A was raised in mouse using the KDIQLARRIRGERA synthetic peptide conjugate to KLH as the immunogen. This antibody exists as a non-conjugated isotype IgG2b, purified by protein A with a purity greater than 95%.
The antibody against HIST1H3A was raised in mouse using the KDIQLARRIRGERA synthetic peptide conjugate to KLH as the immunogen. This antibody exists as a non-conjugated isotype IgG2b, purified by protein A with a purity greater than 95%.
$200.00
Western Blot Positive WB detected in: Raw264.7 whole cell lysate, Raji whole cell lysate, MCF-7 whole cell lysate All lanes: HistoneH3 antibody at 1:20000 Secondary Goat polyclonal to mouse IgG at 1/50000 dilution Predicted band size: 15-25 KDa Observed band size: 15-25 KDa Exposure time: 1min2
Western Blot Positive WB detected in: Rabbit stomach tissue All lanes: HistoneH3 antibody at 1:20000 Secondary Goat polyclonal to mouse IgG at 1/50000 dilution Predicted band size: 15-25 KDa Observed band size: 15-25 KDa Exposure time: 1min3
| Cat.No | ADC-57239A | Clonality | Monoclonal |
|---|---|---|---|
| Host Species | Mouse | Target Name | HIST1H3A |
| Target Synonyms | H3C1, H3C10, H3C11, H3C12, H3C2, H3C3, H3C4, H3C6, H3C7, H3C8, H3FA, H3FB, H3FC HIST1H3C AND, H3FD, H3FF, H3FH, H3FI, H3FJ, H3FK, H3FL, HIST1H3A AND, HIST1H3B AND, HIST1H3D AND, HIST1H3E AND, HIST1H3F AND, HIST1H3G AND, HIST1H3H AND, HIST1H3I AND, HIST1H3J, Histone H3.1, Histone H3/a, Histone H3/b, Histone H3/c, Histone H3/d, Histone H3/f, Histone H3/h, Histone H3/i, Histone H3/j, Histone H3/k, Histone H3/l | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat, Rabbit | Isotype | IgG2b |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein A purified |
| Conjugate | Non-conjugated | Storage | Upon receipt |
| Immunogen Description | KDIQLARRIRGERA synthetic peptide conjugate to KLH | Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. |
|---|---|---|---|
| Uniprot ID | P68431 |
Uniprot Id
P68431
Target Species
Human
Target Name
H3C1
Target Full Name
Histone H3.1
Target Function
Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
Target Involvement
Glioma (GLM)
Target Subcellular Location
Nucleus. Chromosome.
Target Protein Families
Histone H3 family
Target Research Area
Epigenetics and Nuclear Signaling
Target Synonyms
H3 histone family member E pseudogene; H3 histone family; member A; H3/A; H31_HUMAN; H3F3; H3FA; Hist1h3a ; HIST1H3B; HIST1H3C; HIST1H3D; HIST1H3E; HIST1H3F; HIST1H3G; HIST1H3H; HIST1H3I; HIST1H3J; HIST3H3; histone 1; H3a ; Histone cluster 1; H3a; Histone H3 3 pseudogene; Histone H3.1; Histone H3/a; Histone H3/b; Histone H3/c; Histone H3/d; Histone H3/f; Histone H3/h; Histone H3/i; Histone H3/j; Histone H3/k; Histone H3/l
Target Background
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3.
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