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The antibody against Phospho-MLKL-S441 was raised in Rabbit using a synthetic phosphorylated peptide around S441 of mouse MLKL (NP_001297542.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
The antibody against Phospho-MLKL-S441 was raised in Rabbit using a synthetic phosphorylated peptide around S441 of mouse MLKL (NP_001297542.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.
| Cat.No | ADA-11583A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | Phospho-MLKL-S441 |
| Target Synonyms | 9130019I15Rik; Phospho-MLKL-S441 | Form | Liquid |
| Species Reactivity | Human, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.01% thimerosal, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | C6 | Application | ELISA, WB |
| Immunogen Description | A synthetic phosphorylated peptide around S441 of mouse MLKL (NP_001297542.1). | Target Species | Mouse |
|---|---|---|---|
| Immunogen Sequence | EPSQR | Uniprot ID | Q9D2Y4 |
Uniprot Id
Q9D2Y4
Target Synonyms
9130019I15Rik; Phospho-MLKL-S441
Target Background
This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to lack protein kinase activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (Rip3), which is a key signaling molecule in necroptosis pathway. Knockout of this gene in mice showed that it is essential for necroptosis. Alternatively spliced transcript variants have been found for this gene.
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