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MPO Recombinant Monoclonal Antibody

The recombinant antibody against MPO was produced using a synthesized peptide derived from human Myeloperoxidase as the immunogen. This antibody exists as a non-conjugated isotype Rabbit IgG, Affinity-chromatography purified. This antibody has been validated on ELISA, IHC.

ADC-57007A

The recombinant antibody against MPO was produced using a synthesized peptide derived from human Myeloperoxidase as the immunogen. This antibody exists as a non-conjugated isotype Rabbit IgG, Affinity-chromatography purified. This antibody has been validated on ELISA, IHC.

$350.00

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Specifications


Cat.No ADC-57007A ClonalityMonoclonal
Target NameMPOTarget Synonyms84 kDa myeloperoxidase, 89 kDa myeloperoxidase, MPO, Myeloperoxidase (MPO) (EC 1.11.2.2) [Cleaved into: Myeloperoxidase, Myeloperoxidase heavy chain], Myeloperoxidase light chain
FormLiquidSpecies ReactivityHuman
IsotypeRabbit IgGStorage BufferPH 7.4, 0.02% sodium azide and 50% glycerol., 150mM NaCl, Rabbit IgG in phosphate buffered saline
Purification MethodAffinity-chromatography purifiedConjugateNon-conjugated
ApplicationELISA, IHCStorageUpon receipt

Immunogen Information


Immunogen DescriptionA synthesized peptide derived from human MyeloperoxidaseTarget SpeciesHuman
Immunogen SequenceComplete sequences for the immunogen, target protein, and peptides are available upon request.Uniprot IDP05164
Background Information
  • Uniprot Id

    P05164

  • Target Species

    Human

  • Target Name

    MPO

  • Target Full Name

    Myeloperoxidase

  • Target Function

    Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity.

  • Target Involvement

    Myeloperoxidase deficiency (MPOD)

  • Target Subcellular Location

    Lysosome.

  • Target Protein Families

    Peroxidase family, XPO subfamily

  • Target Synonyms

    MPO; Myeloperoxidase (MPO)

  • Target Background

    Myeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation that constitutes the major component of neutrophil azurophilic granules. Produced as a single chain precursor, myeloperoxidase is subsequently cleaved into a light and heavy chain. The mature myeloperoxidase is a tetramer composed of 2 light chains and 2 heavy chains. This enzyme produces hypohalous acids central to the microbicidal activity of neutrophils.

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