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The recombinant antibody against MPO was produced using a synthesized peptide derived from human Myeloperoxidase as the immunogen. This antibody exists as a non-conjugated isotype Rabbit IgG, Affinity-chromatography purified. This antibody has been validated on ELISA, IHC.
The recombinant antibody against MPO was produced using a synthesized peptide derived from human Myeloperoxidase as the immunogen. This antibody exists as a non-conjugated isotype Rabbit IgG, Affinity-chromatography purified. This antibody has been validated on ELISA, IHC.
$350.00
| Cat.No | ADC-57007A | Clonality | Monoclonal |
|---|---|---|---|
| Target Name | MPO | Target Synonyms | 84 kDa myeloperoxidase, 89 kDa myeloperoxidase, MPO, Myeloperoxidase (MPO) (EC 1.11.2.2) [Cleaved into: Myeloperoxidase, Myeloperoxidase heavy chain], Myeloperoxidase light chain |
| Form | Liquid | Species Reactivity | Human |
| Isotype | Rabbit IgG | Storage Buffer | PH 7.4, 0.02% sodium azide and 50% glycerol., 150mM NaCl, Rabbit IgG in phosphate buffered saline |
| Purification Method | Affinity-chromatography purified | Conjugate | Non-conjugated |
| Application | ELISA, IHC | Storage | Upon receipt |
| Immunogen Description | A synthesized peptide derived from human Myeloperoxidase | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P05164 |
Uniprot Id
P05164
Target Species
Human
Target Name
MPO
Target Full Name
Myeloperoxidase
Target Function
Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity.
Target Involvement
Myeloperoxidase deficiency (MPOD)
Target Subcellular Location
Lysosome.
Target Protein Families
Peroxidase family, XPO subfamily
Target Synonyms
MPO; Myeloperoxidase (MPO)
Target Background
Myeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation that constitutes the major component of neutrophil azurophilic granules. Produced as a single chain precursor, myeloperoxidase is subsequently cleaved into a light and heavy chain. The mature myeloperoxidase is a tetramer composed of 2 light chains and 2 heavy chains. This enzyme produces hypohalous acids central to the microbicidal activity of neutrophils.
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