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The antibody against Csf1 was raised in rabbit using the Recombinant Mouse Macrophage colony-stimulating factor 1 protein (33-262AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.
The antibody against Csf1 was raised in rabbit using the Recombinant Mouse Macrophage colony-stimulating factor 1 protein (33-262AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.
$299.00
| Cat.No | ADC-54313A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | CSF1 |
| Target Synonyms | Csf1 antibody; CsfmMacrophage colony-stimulating factor 1 antibody; CSF-1 antibody; MCSF) [Cleaved into: Processed macrophage colony-stimulating factor 1] antibody | Form | Liquid |
| Species Reactivity | Mouse | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Mouse Macrophage colony-stimulating factor 1 protein (33-262AA) | Target Species | Mus musculus (Mouse) |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P07141 |
Uniprot Id
P07141
Target Species
Mouse
Target Name
CSF1
Target Full Name
Macrophage colony-stimulating factor 1
Target Function
Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female fertility. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration. Plays a role in lipoprotein clearance.
Target Involvement
A defect in Csf1 is the cause of osteopetrosis. Osteopetrotic mice (op/op) are severely deficient in mature macrophages and osteoclasts, display failed tooth eruption, and have a restricted capacity for bone remodeling.
Target Subcellular Location
Cell membrane; Single-pass type I membrane protein.; [Processed macrophage colony-stimulating factor 1]: Secreted, extracellular space.
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