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The antibody against Gzma was raised in rabbit using the Recombinant Mouse Granzyme A protein (29-260AA) as the immunogen. This antibody exists as a hrp conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.
The antibody against Gzma was raised in rabbit using the Recombinant Mouse Granzyme A protein (29-260AA) as the immunogen. This antibody exists as a hrp conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.
$299.00
| Cat.No | ADC-24767A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | Gzma |
| Form | Liquid | Species Reactivity | Mouse |
| Isotype | IgG | Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 |
| Purification Method | >95%, Protein G purified | Conjugate | HRP conjugated |
| Application | ELISA | Storage | Upon receipt |
| Immunogen Description | Recombinant Mouse Granzyme A protein (29-260AA) | Target Species | Mus musculus (Mouse) |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P11032 |
Uniprot Id
P11032
Target Species
Mouse
Target Name
GZMA
Target Full Name
Granzyme A
Target Function
Abundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent pyroptosis when delivered into the target cell through the immunological synapse. It cleaves after Lys or Arg. Cleaves APEX1 after 'Lys-31' and destroys its oxidative repair activity. Cleaves the nucleosome assembly protein SET after 'Lys-189', which disrupts its nucleosome assembly activity and allows the SET complex to translocate into the nucleus to nick and degrade the DNA.
Target Subcellular Location
Secreted. Cytoplasmic granule.
Target Protein Families
Peptidase S1 family, Granzyme subfamily
Target Tissue Specificity
Found in cytotoxic lymphocytes and in normal lymphoid tissues such as thymus and spleen.; [Isoform HF1]: More abundant in lymphoid tissues than isoform HF2.
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