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The recombinant antibody against PLEKHA1 was produced using a synthesized peptide derived from human PLEKHA1 as the immunogen. This antibody exists as a non-conjugated isotype Rabbit IgG, Affinity-chromatography purified. This antibody has been validated on ELISA, WB.
The recombinant antibody against PLEKHA1 was produced using a synthesized peptide derived from human PLEKHA1 as the immunogen. This antibody exists as a non-conjugated isotype Rabbit IgG, Affinity-chromatography purified. This antibody has been validated on ELISA, WB.
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Western Blot | Positive WB detected in: Hela whole cell lysate, A549 whole cell lysate, PC-3 whole cell lysate, MCF-7 whole cell lysate | All lanes: PLEKHA1 antibody at 1:1000 | Secondary | Goat polyclonal to rabbit IgG at 1/50000 dilution | Predicted band size: 46, 39 kDa | Observed band size: 36-55 kDa
| Cat.No | ADC-56627A | Clonality | Monoclonal |
|---|---|---|---|
| Target Name | PLEKHA1 | Target Synonyms | Pleckstrin homology domain-containing family A member 1 (PH domain-containing family A member 1) (Tandem PH domain-containing protein 1) (TAPP-1), PLEKHA1, TAPP1 |
| Form | Liquid | Species Reactivity | Human |
| Isotype | Rabbit IgG | Storage Buffer | PH 7.4, 0.02% sodium azide and 50% glycerol., 150mM NaCl, Rabbit IgG in phosphate buffered saline |
| Purification Method | Affinity-chromatography purified | Conjugate | Non-conjugated |
| Application | ELISA, WB | Storage | Upon receipt |
| Immunogen Description | A synthesized peptide derived from human PLEKHA1 | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | Q9HB21 |
Uniprot Id
Q9HB21
Target Species
Human
Target Name
PLEKHA1
Target Full Name
Pleckstrin homology domain-containing family A member 1
Target Function
Binds specifically to phosphatidylinositol 3,4-diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane.
Target Subcellular Location
Cytoplasm. Cell membrane; Peripheral membrane protein. Nucleus.
Target Tissue Specificity
Highly expressed in skeletal muscle, thymus, pancreas, placenta and lung. Detected at low levels in brain, heart, peripheral blood leukocytes, testis, ovary, spinal cord, thyroid, kidney, liver, small intestine and colon.
Target Synonyms
OTTHUMP00000020651; PH domain containing family A member 1; PH domain-containing family A member 1; PKHA1_HUMAN; Pleckstrin homology domain containing A1; Pleckstrin homology domain containing family A member 1; Pleckstrin homology domain containing, family A (phosphoinositide binding specific) member; Pleckstrin homology domain-containing family A member 1; PLEKHA1; Tandem PH domain containing protein 1; Tandem PH domain-containing protein 1; TAPP 1; TAPP-1; TAPP1
Target Background
This gene encodes a pleckstrin homology domain-containing adapter protein. The encoded protein is localized to the plasma membrane where it specifically binds phosphatidylinositol 3, 4-bisphosphate. This protein may be involved in the formation of signaling complexes in the plasma membrane. Polymorphisms in this gene are associated with age-related macular degeneration. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 5.
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