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The antibody against DOT5 was raised in rabbit using the Recombinant S. cerevisiae DOT5 protein (37-118aa) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Affinity-chromatography purified. This antibody has been validated on ELISA, WB.
The antibody against DOT5 was raised in rabbit using the Recombinant S. cerevisiae DOT5 protein (37-118aa) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Affinity-chromatography purified. This antibody has been validated on ELISA, WB.
$299.00
Western Blot | Positive WB detected in: recombinant protein | All lanes: DOT5 Antibody at 1:1000 | Secondary | Goat polyclonal to rabbit IgG at 1/50000 dilution | Predicted band size: 25 kDa | Observed band size: 25 kDa
| Cat.No | ADC-54651A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | DOT5 |
| Target Synonyms | DOT5, Peroxiredoxin DOT5 (Prx) (EC 1.11.1.15) (Disrupter of telomere silencing protein 5) (Nuclear thiol peroxidase) (nTPx) (Thioredoxin peroxidase) | Form | Liquid |
| Species Reactivity | S. cerevisiae | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | Affinity-chromatography purified |
| Conjugate | Non-conjugated | Application | ELISA, WB |
| Storage | Upon receipt |
| Immunogen Description | Recombinant S. cerevisiae DOT5 protein (37-118aa) | Target Species | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P40553 |
Uniprot Id
P40553
Target Species
Yeast
Target Name
DOT5
Target Function
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Has a role in telomere silencing, which is the repression of chromatin structure which leads to a stop in the transcription of nearby genes. Also has a role in the regulation of telomere length. Acts as an alkyl-hydroperoxide reductase in the nucleus during post-diauxic growth. Preferentially reduces alkyl-hydroperoxides rather than hydrogen peroxide. Acts as an antioxidant necessary for stationary phase survival.
Target Subcellular Location
Nucleus. Chromosome, telomere.
Target Protein Families
Peroxiredoxin family, BCP/PrxQ subfamily
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