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The antibody against SNF1 was raised in rabbit using the Recombinant Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) SNF1 protein (435-633aa) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Protein G Purified. This antibody has been validated on ELISA, WB.
The antibody against SNF1 was raised in rabbit using the Recombinant Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker’s yeast) SNF1 protein (435-633aa) as the immunogen. This antibody exists as a non-conjugated isotype IgG, Protein G Purified. This antibody has been validated on ELISA, WB.
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Western BlotPositive WB detected in Recombinant proteinAll lanes: SNF1 antibody at 1:2000SecondaryGoat polyclonal to rabbit IgG at 1/50000 dilutionPredicted band size: 38.2 kDaObserved band size: 36 kDa
| Cat.No | ADC-55314A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | SNF1 |
| Target Synonyms | Carbon catabolite-derepressing protein kinase (EC 2.7.11.1) (Sucrose nonfermentating protein 1) SNF1 CAT1 CCR1 GLC2 PAS14 YDR477W D8035.20 | Form | Liquid |
| Species Reactivity | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA, WB |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) SNF1 protein (435-633aa) | Target Species | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P06782 |
Uniprot Id
P06782
Target Species
Yeast
Target Name
SNF1
Target Function
Serine/threonine protein kinase essential for release from glucose repression. Catalytic subunit of the AMP-activated protein kinase complex also known as the SNF1 kinase complex (Snf1c), a central regulator of cellular energy homeostasis, which, in response to a fall in intracellular ATP levels, activates energy-producing pathways and inhibits energy-consuming processes. The complex phosphorylates histone H3 to form H3S10ph, which promotes H3K14ac formation, leading to transcriptional activation through TBP recruitment to the promoters. The complex also negatively regulates the HOG1 MAPK pathway in ER stress response including unfolded protein response (UPR). Under nutrient/energy depletion, the complex phosphorylates and activates PAS kinase PSK1 which in turn activates PBS1, leading to the inhibition of the TORC1 signaling pathway. SNF1 also interacts and phosphorylates adenylate cyclase CYR1 and negatively regulates the protein kinase A signaling pathway. Also phosphorylates and regulates the transcriptional activator CAT8.
Target Subcellular Location
Cytoplasm. Nucleus. Nucleus membrane; Peripheral membrane protein.
Target Protein Families
Protein kinase superfamily, CAMK Ser/Thr protein kinase family, SNF1 subfamily
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