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The antibody against Dio3 was raised in rabbit using the Recombinant Rat Thyroxine 5-deiodinase protein (37-278AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.
The antibody against Dio3 was raised in rabbit using the Recombinant Rat Thyroxine 5-deiodinase protein (37-278AA) as the immunogen. This antibody exists as a non-conjugated isotype IgG, purified by protein G with a purity greater than 95%. This antibody has been validated on ELISA.
$299.00
| Cat.No | ADC-49396A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | DIO3 |
| Target Synonyms | Dio3 antibody; Itdi3 antibody; Txdi3 antibody; Thyroxine 5-deiodinase antibody; EC 1.21.99.3 antibody; 5DIII antibody; DIOIII antibody; Type 3 DI antibody; Type III iodothyronine deiodinase antibody | Form | Liquid |
| Species Reactivity | Rat | Isotype | IgG |
| Storage Buffer | 0.01M PBS, 0.03% Proclin 300; Constituents: 50% Glycerol, PH 7.4 | Purification Method | >95%, Protein G purified |
| Conjugate | Non-conjugated | Application | ELISA |
| Storage | Upon receipt |
| Immunogen Description | Recombinant Rat Thyroxine 5-deiodinase protein (37-278AA) | Target Species | Rattus norvegicus (Rat) |
|---|---|---|---|
| Immunogen Sequence | Complete sequences for the immunogen, target protein, and peptides are available upon request. | Uniprot ID | P49897 |
Uniprot Id
P49897
Target Species
Rat
Target Name
DIO3
Target Full Name
Thyroxine 5-deiodinase
Target Function
Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into RT3 (3,3',5'-triiodothyronine) and of T3 (3,5,3'-triiodothyronine) into T2 (3,3'-diiodothyronine). RT3 and T2 are inactive metabolites. May play a role in preventing premature exposure of developing fetal tissues to adult levels of thyroid hormones. Can regulate circulating fetal thyroid hormone concentrations throughout gestation. Essential role for regulation of thyroid hormone inactivation during embryological development.
Target Subcellular Location
Cell membrane; Single-pass type II membrane protein. Endosome membrane; Single-pass type II membrane protein.
Target Protein Families
Iodothyronine deiodinase family
Target Tissue Specificity
Neonatal skin, placenta, skeletal muscle and cerebral cortex.
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