Recombinant Human 11-cis retinol dehydrogenase (RDH5)

Cat.No	ACP12679	Target Name	RDH5
Form	Lyophilized powder	Expression System	Custom Production. Please inquire and provide the desire expression system.
Expression Range	24-318	Protein Length	Full Length of Mature Protein
Purity	>85% (SDS-PAGE)	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP12679

Target Name

RDH5

Form

Lyophilized powder

Expression System

Custom Production. Please inquire and provide the desire expression system.

Expression Range

24-318

Protein Length

Full Length of Mature Protein

Purity

>85% (SDS-PAGE)

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	Q92781

Background Information

Uniprot Id

Q92781
Target Species

Human
Target Name

RDH5
Target Full Name

Retinol dehydrogenase 5
Target Function

Catalyzes the oxidation of cis-isomers of retinol, including 11-cis-, 9-cis-, and 13-cis-retinol in an NAD-dependent manner. Has no activity towards all-trans retinal. Plays a significant role in 11-cis retinol oxidation in the retinal pigment epithelium cells (RPE). Also recognizes steroids (androsterone, androstanediol) as its substrates.
Target Involvement

Fundus albipunctatus (FALBI)
Target Subcellular Location

Endoplasmic reticulum membrane; Multi-pass membrane protein; Lumenal side.
Target Protein Families

Short-chain dehydrogenases/reductases (SDR) family
Target Tissue Specificity

Widely expressed. In the eye, abundant in the retinal pigment epithelium.
Target Synonyms

RDH5; HSD17B9; RDH1; SDR9C5; Retinol dehydrogenase 5; EC 1.1.1.209; EC 1.1.1.315; EC 1.1.1.53; 11-cis retinol dehydrogenase; 11-cis RDH; 11-cis RoDH; 9-cis retinol dehydrogenase; 9cRDH; Short chain dehydrogenase/reductase family 9C member 5
Target Background

This gene encodes an enzyme belonging to the short-chain dehydrogenases/reductases (SDR) family. This retinol dehydrogenase functions to catalyze the final step in the biosynthesis of 11-cis retinaldehyde, which is the universal chromophore of visual pigments. Mutations in this gene cause autosomal recessive fundus albipunctatus, a rare form of night blindness that is characterized by a delay in the regeneration of cone and rod photopigments. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring upstream BLOC1S1 (biogenesis of lysosomal organelles complex-1, subunit 1) gene.

Recombinant Human 11-cis retinol dehydrogenase (RDH5)

Specifications

Immunogen Information

Inquire Recombinant Human 11-cis retinol dehydrogenase (RDH5) Now

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