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Recombinant Human 2′,5′-phosphodiesterase 12 (PDE12)

ACP16022

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Specifications

Cat.No	ACP16022	Target Name	PDE12
Target Synonyms	2 PDE; 2' 5' phosphodiesterase 12; 2' phosphodiesterase; 2', 5'-phosphodiesterase 12; 2'-PDE; 2-PDE; 2PDE; DKFZp667B1218; Pde12; PDE12_HUMAN; Phosphodiesterase 12	Form	Lyophilized powder
Expression System	Custom Production. Please inquire and provide the desire expression system.	Expression Range	1-609
Protein Length	Full length protein	Purity	>85% (SDS-PAGE)
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Immunogen Information

Target Species	Human	Uniprot ID	Q6L8Q7

Background Information

Uniprot Id

Q6L8Q7
Target Species

Human
Target Name

PDE12
Target Full Name

2',5'-phosphodiesterase 12
Target Function

Enzyme that cleaves 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. Degrades triphosphorylated 2-5A to produce AMP and ATP. Also cleaves 3',5'-phosphodiester bond of oligoadenylates. Plays a role as a negative regulator of the 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferons (IFNs). Suppression of this enzyme increases cellular 2-5A levels and decreases viral replication in cultured small-airway epithelial cells and Hela cells
Target Subcellular Location

Mitochondrion matrix.
Target Protein Families

CCR4/nocturin family
Target Tissue Specificity

Ubiquitous.
Target Synonyms

2 PDE; 2' 5' phosphodiesterase 12; 2' phosphodiesterase; 2',5'-phosphodiesterase 12; 2'-PDE; 2-PDE; 2PDE; DKFZp667B1218; Pde12; PDE12_HUMAN; Phosphodiesterase 12

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Recombinant Human 2′,5′-phosphodiesterase 12 (PDE12)

Specifications

Immunogen Information

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