Recombinant Human 2-acylglycerol O-acyltransferase 3 (MOGAT3), Truncated

Uniprot Id

Q86VF5

Target Species

Human

Target Name

MOGAT3

Target Full Name

2-acylglycerol O-acyltransferase 3

Target Function

Catalyzes the formation of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA. Also able to catalyze the terminal step in triacylglycerol synthesis by using diacylglycerol and fatty acyl-CoA as substrates. Has a preference toward palmitoyl-CoA and oleoyl-CoA. May be involved in absorption of dietary fat in the small intestine by catalyzing the resynthesis of triacylglycerol in enterocytes. Also able to use 1-monoalkylglycerol (1-MAkG) as an acyl acceptor for the synthesis of monoalkyl-monoacylglycerol (MAMAG).

Target Subcellular Location

Endoplasmic reticulum membrane; Multi-pass membrane protein. Cytoplasm, perinuclear region.

Target Protein Families

Diacylglycerol acyltransferase family

Target Tissue Specificity

Selectively expressed in the digestive system. Highly expressed in the ileum, and at lower level in jejunum, duodenum, colon, cecum and the rectum. Not expressed in the stomach and the esophagus and trachea. Expressed at very low level in liver.

Target Synonyms

MOGAT3; DC7; DGAT2L7; UNQ9383/PRO34208; 2-acylglycerol O-acyltransferase 3; Acyl-CoA:monoacylglycerol acyltransferase 3; MGAT3; Diacylglycerol O-acyltransferase candidate 7; hDC7; Diacylglycerol acyltransferase 2-like protein 7; Monoacylglycerol O-acyltransferase 3