Recombinant Human 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase (ACMSD)

Uniprot Id

Q8TDX5

Target Species

Human

Target Name

ACMSD

Target Full Name

2-amino-3-carboxymuconate-6-semialdehyde decarboxylase

Target Function

Converts alpha-amino-beta-carboxymuconate-epsilon-semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). ACMS can be converted non-enzymatically to quinolate (QA), a key precursor of NAD, and a potent endogenous excitotoxin of neuronal cells which is implicated in the pathogenesis of various neurodegenerative disorders. In the presence of ACMSD, ACMS is converted to AMS, a benign catabolite. ACMSD ultimately controls the metabolic fate of tryptophan catabolism along the kynurenine pathway.

Target Protein Families

Metallo-dependent hydrolases superfamily, ACMSD family

Target Synonyms

2 amino 3 carboxymuconate 6 semialdehyde decarboxylase; 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase; acmsd; ACMSD_HUMAN; Aminocarboxymuconate semialdehyde decarboxylase; Picolinate carboxylase

Target Background

The neuronal excitotoxin quinolinate is an intermediate in the de novo synthesis pathway of NAD from tryptophan, and has been implicated in the pathogenesis of several neurodegenerative disorders. Quinolinate is derived from alpha-amino-beta-carboxy-muconate-epsilon-semialdehyde (ACMS). ACMSD (ACMS decarboxylase; EC 4.1.1.45) can divert ACMS to a benign catabolite and thus prevent the accumulation of quinolinate from ACMS.