Recombinant Human 2-oxoglutarate dehydrogenase-like, mitochondrial (OGDHL), Truncated

Uniprot Id

Q9ULD0

Target Species

Human

Target Name

OGDHL

Target Full Name

2-oxoglutarate dehydrogenase-like, mitochondrial

Target Function

2-oxoglutarate dehydrogenase (E1-like) component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDHC) which mediates the decarboxylation of alpha-ketoglutarate in the tricarboxylic acid cycle. The OGDHC complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) while reducing NAD(+) to NADH. The OGDHC complex is mainly active in the mitochondrion. Involved in the inhibition of cell proliferation and in apoptosis.

Target Subcellular Location

Mitochondrion matrix.

Target Protein Families

Alpha-ketoglutarate dehydrogenase family

Target Tissue Specificity

Expressed in the brain and the liver.

Target Synonyms

2-oxoglutarate dehydrogenase complex component E1-like; 2-oxoglutarate dehydrogenase-like, mitochondrial; Alpha-ketoglutarate dehydrogenase-like; KIAA1290; OGDC-E1-like; OGDHL; OGDHL_HUMAN

Target Background

The protein encoded by this gene is similar to oxoglutarate dehydrogenase (OGDH) of the OGDH complex, which degrades glucose and glutamate. This gene encodes several isoforms, including some that appear to localize to mitochondria. The encoded protein down-regulates the AKT signaling cascade and can suppress the growth of cervical cancer cells.