Recombinant Human 26S proteasome non-ATPase regulatory subunit 10 (PSMD10)

Cat.No	ACP03964	Target Name	PSMD10
Target Synonyms	10; Proteasome 26S S10; PSD10_HUMAN; Psmd10, macropain) 26S subunit, non-ATPase	Form	Liquid or Lyophilized powder
Expression System	E.coli	Expression Range	1-226aa
Mol Weight	40.4kDa	Protein Length	Full length
Purity	Greater than 90% as determined by SDS-PAGE.	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP03964

Target Name

PSMD10

Target Synonyms

10; Proteasome 26S S10; PSD10_HUMAN; Psmd10, macropain) 26S subunit, non-ATPase

Form

Liquid or Lyophilized powder

Expression System

E.coli

Expression Range

1-226aa

Mol Weight

40.4kDa

Protein Length

Full length

Purity

Greater than 90% as determined by SDS-PAGE.

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	O75832

Background Information

Uniprot Id

O75832
Target Species

Human
Target Name

PSMD10
Target Full Name

26S proteasome non-ATPase regulatory subunit 10
Target Function

Acts as a chaperone during the assembly of the 26S proteasome, specifically of the PA700/19S regulatory complex (RC). In the initial step of the base subcomplex assembly is part of an intermediate PSMD10:PSMC4:PSMC5:PAAF1 module which probably assembles with a PSMD5:PSMC2:PSMC1:PSMD2 module. Independently of the proteasome, regulates EGF-induced AKT activation through inhibition of the RHOA/ROCK/PTEN pathway, leading to prolonged AKT activation. Plays an important role in RAS-induced tumorigenesis.; Acts as an proto-oncoprotein by being involved in negative regulation of tumor suppressors RB1 and p53/TP53. Overexpression is leading to phosphorylation of RB1 and proteasomal degradation of RB1. Regulates CDK4-mediated phosphorylation of RB1 by competing with CDKN2A for binding with CDK4. Facilitates binding of MDM2 to p53/TP53 and the mono- and polyubiquitination of p53/TP53 by MDM2 suggesting a function in targeting the TP53:MDM2 complex to the 26S proteasome. Involved in p53-independent apoptosis. Involved in regulation of NF-kappa-B by retaining it in the cytoplasm. Binds to the NF-kappa-B component RELA and accelerates its XPO1/CRM1-mediated nuclear export.
Target Subcellular Location

Cytoplasm. Nucleus.
Target Tissue Specificity

Tends to be up-regulated in cancer cells with RAS mutations, including lung cancers and adenocarconimas (at protein level).
Target Research Area

Cancer
Target Synonyms

26S proteasome non-ATPase regulatory subunit 10; 26S proteasome regulatory subunit p28; Ankyrin repeat protein; dJ889N15.2; Gankyrin; Hepatocellular carcinoma-associated protein p28 II; p28; p28(GANK); Proteasome (prosome, macropain) 26S subunit, non ATPase, 10; Proteasome 26S S10; PSD10_HUMAN; Psmd10
Target Background

This gene encodes a subunit of the PA700/19S complex, which is the regulatory component of the 26S proteasome. The 26S proteosome complex is required for ubiquitin-dependent protein degradation. This protein is a non-ATPase subunit that may be involved in protein-protein interactions. Aberrant expression of this gene may paly a role in tumorigenesis. Two transcripts encoding different isoforms have been described. Pseudogenes have been identified on chromosomes 3 and 20.

Recombinant Human 26S proteasome non-ATPase regulatory subunit 10 (PSMD10)

Specifications

Immunogen Information

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