Recombinant Human 28S ribosomal protein S14, mitochondrial (MRPS14)

Uniprot Id

O60783

Target Species

Human

Target Name

MRPS14

Target Full Name

Small ribosomal subunit protein uS14m

Target Subcellular Location

Mitochondrion.

Target Protein Families

Universal ribosomal protein uS14 family

Target Synonyms

MRPS14; 28S ribosomal protein S14; mitochondrial; MRP-S14; S14mt; Mitochondrial small ribosomal subunit protein uS14m

Target Background

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S14P family. Alternative splicing results in multiple transcript variants.