Recombinant Human 28S ribosomal protein S36, mitochondrial (MRPS36)

Uniprot Id

P82909

Target Species

Human

Target Name

KGD4

Target Full Name

Alpha-ketoglutarate dehydrogenase component 4

Target Function

May be necessary to recruit DLD/E3 to the mitochondrial 2-oxoglutarate dehydrogenase complex (OGDC) core composed of OGDH/E1 and DLST/E2, hence stabilizes the complex.

Target Subcellular Location

Mitochondrion.

Target Synonyms

1110018B13Rik; 28S ribosomal protein S36; DC47; MGC22896; mitochondrial; MRP-S36; MRPS36; OTTHUMP00000222036; RT36_HUMAN; S36mt

Target Background

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. The mitochondrial ribosome (mitoribosome) consists of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein. Pseudogenes corresponding to this gene are found on chromosomes 3p, 4q, 8p, 11q, 12q, and 20p.