Recombinant Human 39S ribosomal protein L1, mitochondrial (MRPL1)

Uniprot Id

Q9BYD6

Target Species

Human

Target Name

MRPL1

Target Full Name

Large ribosomal subunit protein uL1m

Target Subcellular Location

Mitochondrion.

Target Protein Families

Universal ribosomal protein uL1 family

Target Research Area

Epigenetics and Nuclear Signaling

Target Synonyms

39S ribosomal protein L1; 39S ribosomal protein L1, mitochondrial precursor; BM022; L1mt; mitochondrial; Mitochondrial ribosomal protein L1; MRP L1; MRP-L1; Mrpl1; RM01_HUMAN

Target Background

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the L1 ribosomal protein family.