Recombinant Human 39S ribosomal protein L40, mitochondrial (MRPL40)

Uniprot Id

Q9NQ50

Target Species

Human

Target Name

MRPL40

Target Full Name

Large ribosomal subunit protein mL40

Target Subcellular Location

Mitochondrion.

Target Protein Families

Mitochondrion-specific ribosomal protein mL40 family

Target Tissue Specificity

Ubiquitous.

Target Synonyms

MRPL40; NLVCF; URIM; 39S ribosomal protein L40; mitochondrial; L40mt; MRP-L40; Mitochondrial large ribosomal subunit protein mL40; Nuclear localization signal-containing protein deleted in velocardiofacial syndrome; Up-regulated in metastasis

Target Background

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Deletions in this gene may contribute to the etiology of velo-cardio-facial syndrome and DiGeorge syndrome.