Recombinant Human 39S ribosomal protein L51, mitochondrial (MRPL51)

Uniprot Id

Q4U2R6

Target Species

Human

Target Name

MRPL51

Target Full Name

Large ribosomal subunit protein mL51

Target Subcellular Location

Mitochondrion.

Target Protein Families

Mitochondrion-specific ribosomal protein mL51 family

Target Synonyms

39S ribosomal protein L51; 39S ribosomal protein L51 mitochondrial; bMRP-64; bMRP64; CDA09; HSPC241; L51mt; mitochondrial; mitochondrial ribosomal protein 64; mitochondrial ribosomal protein bMRP64; mitochondrial ribosomal protein L51 ; MRP-L51; MRP64; mrpl51; RM51_HUMAN

Target Background

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Pseudogenes corresponding to this gene are found on chromosomes 4p and 21q.