Recombinant Human 39S ribosomal protein L52, mitochondrial (MRPL52)

Uniprot Id

Q86TS9

Target Species

Human

Target Name

MRPL52

Target Full Name

Large ribosomal subunit protein mL52

Target Subcellular Location

Mitochondrion.

Target Protein Families

Mitochondrion-specific ribosomal protein mL52 family

Target Synonyms

39S ribosomal protein L52; L52mt; mitochondrial; MRP-L52; Mrpl52; RM52_HUMAN

Target Background

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein which has no bacterial homolog. Multiple transcript variants encoding different protein isoforms were identified through sequence analysis.